› 7mja

X-ray diffraction
1.69Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-105412 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 32.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A5H2UYS3 (Residues: 27-306; Coverage: 82%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Paired mesoderm homeobox protein 2B Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q99453 (Residues: 43-51; Coverage: 3%)
Gene names: PHOX2B, PMX2B

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P41212
Unit cell:
a: 77.211Å b: 77.211Å c: 174.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.175 0.199
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

28 review citations

Engineered cellular immunotherapies in cancer and beyond.
Finck et al. (2022)
27 more

4 mentions without citation

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Yarmarkovich et al. (2021)
3 more