› 7mkb

X-ray diffraction
1.9Å resolution

Human leukocyte antigen A*0201 in complex with SARS-CoV-2 epitope YLQPRTFLL

Released:
DOI: 10.2210/pdb7mkb/pdb
PDB entry 7mkb coloured by chain, front view.
PDB entry 7mkb coloured by chain, side view.
PDB entry 7mkb coloured by chain, top view.
Source organisms:
Entry authors: Nyovanie ST, Patskovsky Y, Krogsgaard M

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-102960 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A140T913 (Residues: 25-298; Coverage: 79%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Spike protein S1 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.15 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Not provided
UniProt:
  • Canonical: P0DTC2 (Residues: 269-277; Coverage: 1%)
Gene names: 2, S

Ligands and Environments

1 bound ligand:
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 64.691Å b: 78.491Å c: 92.491Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.164 0.209
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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