› 7mkg

Electron Microscopy
3.07Å resolution

Straight tau filament extracted from PrP-CAA Patient brain tissue | tau filament | SF Tau

Released:
DOI: 10.2210/pdb7mkg/pdb
PDB entry 7mkg coloured by chain, front view.
PDB entry 7mkg coloured by chain, side view.
PDB entry 7mkg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Tau filaments in Prion protein amyloidoses.
Hallinan GI, Hoq MR, Ghosh M, Vago FS, Fernandez A, Garringer HJ, Vidal R, Jiang W, Ghetti B
Acta Neuropathol 142 227-241 (2021)
PMID: 34128081
Related structures: EMD-23890

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145394 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.07Å
Relevant EMDB volumes: EMD-23890

Quick links

Citations

5 review citations

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Scheres et al. (2023)
4 more

6 mentions without citation

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.
Pinzi et al. (2023)
5 more