› 7mla

Solution NMR

Solution NMR structure of HDMX in complex with Zn and MCo-52-2

Released:
DOI: 10.2210/pdb7mla/pdb
PDB entry 7mla coloured by chain, ensemble of 20 models, front view.
PDB entry 7mla coloured by chain, ensemble of 20 models, side view.
PDB entry 7mla coloured by chain, ensemble of 20 models, top view.
Source organisms:
Entry authors: Ramirez LS, Theophall G, Chaudhuri D, Camarero JC, Shekhtman A

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127325 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chain: A
Molecule details ›
Chain: A
Length: 70 amino acids
Theoretical weight: 7.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15151 (Residues: 428-490; Coverage: 13%)
Gene names: MDM4, MDMX
Sequence domains: Zinc finger, C3HC4 type (RING finger)
MCo-52-2 Chain: B
Molecule details ›
Chain: B
Length: 34 amino acids
Theoretical weight: 3.6 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: molecular dynamics
Expression systems:
  • Escherichia coli
  • Not provided

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