7n19

X-ray diffraction
2.38Å resolution

DR3 in complex with Aspergillus nidulans NAD-dependent histone deacetylase hst4 peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135354 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 181 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Ig-like domain-containing protein Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 189 amino acids
Theoretical weight: 22.05 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q5Y7D1 (Residues: 33-219; Coverage: 79%)
Gene names: HLA-DRB1, RP1-93N13.1-001
Sequence domains:
HST4 peptide Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 14 amino acids
Theoretical weight: 1.38 KDa
Source organism: synthetic construct
Expression system: Trichoplusia ni

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 74.461Å b: 214.255Å c: 74.554Å
α: 90° β: 98.956° γ: 90°
R-values:
R R work R free
0.202 0.2 0.248
Expression system: Trichoplusia ni