› 7n2q

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-233109 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
AS4.3 T cell receptor alpha chain Chains: D, E
Molecule details ›
Chains: D, E
Length: 204 amino acids
Theoretical weight: 22.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
AS4.3 T cell receptor beta chain Chains: F, G
Molecule details ›
Chains: F, G
Length: 241 amino acids
Theoretical weight: 27.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Ig-like domain-containing protein Chains: A, H
Beta-2-microglobulin Chains: B, I
UPF0324 inner membrane protein YeiH Chains: C, J

Ligands and Environments

3 bound ligands:
Ligand NAG 6 x NAG
Ligand SO4 4 x SO4
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL12-1
Spacegroup: P21
Unit cell:
a: 54.977Å b: 97.412Å c: 175.484Å
α: 90° β: 92.325° γ: 90°
R-values:
R R work R free
0.216 0.213 0.264
Expression systems:
  • Homo sapiens
  • Escherichia coli
  • Not provided

Quick links

Citations

12 review citations

EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders.
Kuiper et al. (2023)
11 more

3 mentions without citation

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Yang et al. (2022)
2 more