› 7n8q

X-ray diffraction
2.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-207302 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein Chains: A, G
Molecule details ›
Chains: A, G
Length: 355 amino acids
Theoretical weight: 39.36 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0M3KKW9 (Residues: 1-353; Coverage: 100%)
Gene name: HIV-1 Env
Sequence domains: Envelope glycoprotein GP120
M48U1 CD4 MIMETIC PEPTIDE Chain: N
Molecule details ›
Chain: N
Length: 28 amino acids
Theoretical weight: 3.06 KDa
Source organism: synthetic construct
Expression system: Not provided
Rhesusized DH677.3 FAB HEAVY CHAIN Chains: C, H
Molecule details ›
Chains: C, H
Length: 228 amino acids
Theoretical weight: 24.54 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
Rhesusized DH677.3 FAB LIGHT CHAIN Chains: D, L
Molecule details ›
Chains: D, L
Length: 214 amino acids
Theoretical weight: 23.25 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 18 x NAG
2 modified residues:
Ligand DPR 1 x DPR
Ligand U2X 1 x U2X

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21
Unit cell:
a: 99.182Å b: 82.664Å c: 111.899Å
α: 90° β: 112.02° γ: 90°
R-values:
R R work R free
0.257 0.255 0.296
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

1 citations in other articles

Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among humans and rhesus macaques.
Tuyishime et al. (2023)

1 mention without citation

Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s.
Tolbert et al. (2021)