› 7ndu

X-ray diffraction
2.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-100466 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Soluble HLA class I histocompatibility antigen, alpha chain E Chain: AAA
Molecule details ›
Chain: AAA
Length: 277 amino acids
Theoretical weight: 31.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13747 (Residues: 22-297; Coverage: 82%)
Gene names: HLA-6.2, HLA-E, HLAE
Sequence domains:
Beta-2-microglobulin Chain: BBB
Molecule details ›
Chain: BBB
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Gag6V(276-284 H4C) Chain: CCC
M1-specific T cell receptor alpha chain; T cell receptor alpha joining 23; T cell receptor alpha variable 4 Chain: DDD
Ig-like domain-containing protein; T cell receptor beta joining 1-2; T cell receptor beta variable 7-9 Chain: EEE

Ligands and Environments

No bound ligands
1 modified residue:
Ligand QM8 1 x QM8

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P43212
Unit cell:
a: 88.98Å b: 88.98Å c: 293.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.242 0.302
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 citation in other articles

HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.
Lin et al. (2023)
3 more