› 7nmf

X-ray diffraction
2.98Å resolution

Human MHC Class I, A24 Allele presenting QLPRLFPLL, Complex with 4C6 TCR, monoclinic form

Released:
DOI: 10.2210/pdb7nmf/pdb
PDB entry 7nmf coloured by chain, front view.
PDB entry 7nmf coloured by chain, side view.
PDB entry 7nmf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rizkallah PJ, Sewell AK, Cole DK, Wall A

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-207488 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A5H2UYS3 (Residues: 27-302; Coverage: 81%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
GLN-LEU-PRO-ARG-LEU-PHE-PRO-LEU-LEU Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
Human T-cell Receptor 4C6, alpha Chain Chain: D
Molecule details ›
Chain: D
Length: 194 amino acids
Theoretical weight: 21.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Human T-cell Receptor 4C6, beta Chain Chain: E
Molecule details ›
Chain: E
Length: 240 amino acids
Theoretical weight: 27.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

3 bound ligands:
Ligand MES 1 x MES
Ligand EDO 1 x EDO
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 63.38Å b: 72.25Å c: 114.84Å
α: 90° β: 102.98° γ: 90°
R-values:
R R work R free
0.186 0.182 0.259
Expression systems:
  • Escherichia coli
  • Not provided

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