› 7nmi

X-ray diffraction
2.1Å resolution

Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization chaperone

Released:
DOI: 10.2210/pdb7nmi/pdb
Model geometry
Fit model/data
PDB entry 7nmi coloured by chain, front view.
PDB entry 7nmi coloured by chain, side view.
PDB entry 7nmi coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ecsedi P, Nyitray L

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138106 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cellular tumor antigen p53 Chain: A
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04637 (Residues: 17-56; Coverage: 10%)
Gene names: P53, TP53
Sequence domains:
Annexin A2; Protein S100-P Chain: B
Molecule details ›
Chain: B
Length: 512 amino acids
Theoretical weight: 57.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25815 (Residues: 1-95; Coverage: 100%)
  • Canonical: P07355 (Residues: 29-339; Coverage: 92%)
Gene names: ANX2, ANX2L4, ANXA2, CAL1H, LPC2D, S100E, S100P
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 65.92Å b: 86.77Å c: 113.42Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.228
Expression system: Escherichia coli BL21(DE3)

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