› 7nrt

Electron Microscopy
2.68Å resolution

Conformation 2 of straight filament from primary age-related tauopathy brain

Released:
DOI: 10.2210/pdb7nrt/pdb
PDB entry 7nrt coloured by chain, front view.
PDB entry 7nrt coloured by chain, side view.
PDB entry 7nrt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Shi Y, Murzin AG, Falcon B, Epstein A, Machin J, Tempest P, Newell KL, Vidal R, Garringer HJ, Sahara N, Higuchi M, Ghetti B, Jang MK, Scheres SHW, Goedert M
Acta Neuropathol 141 697-708 (2021)
PMID: 33723967
Related structures: EMD-12550

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145394 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.68Å
Relevant EMDB volumes: EMD-12550

Quick links

Citations

19 review citations

Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies.
Magalhães et al. (2022)
18 more

2 mentions without citation

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.
Pinzi et al. (2023)
1 more