› 7nui

X-ray diffraction
2Å resolution

Crystal structure of HLA-B*08:01 in complex with ELRSRYWAI viral peptide

Released:
DOI: 10.2210/pdb7nui/pdb
PDB entry 7nui coloured by chain, front view.
PDB entry 7nui coloured by chain, side view.
PDB entry 7nui coloured by chain, top view.
Source organisms:
Entry authors: Mavridis G, Giastas P, Mpakali A

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-158317 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA-B*08:01 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Nucleoprotein Chain: D
Molecule details ›
Chain: D
Length: 9 amino acids
Theoretical weight: 1.2 KDa
Source organism: Influenza A virus
Expression system: Not provided
UniProt:
  • Canonical: Q9Q0U8 (Residues: 380-388; Coverage: 2%)
Gene name: NP

Ligands and Environments

2 bound ligands:
Ligand EDO 4 x EDO
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: C2
Unit cell:
a: 90.236Å b: 40.206Å c: 125.978Å
α: 90° β: 101.53° γ: 90°
R-values:
R R work R free
0.232 0.23 0.282
Expression systems:
  • Escherichia coli BL21
  • Not provided

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