› 7nup

X-ray diffraction
3.1Å resolution

Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand

Released:
DOI: 10.2210/pdb7nup/pdb
Model geometry
Fit model/data
PDB entry 7nup coloured by chain, front view.
PDB entry 7nup coloured by chain, side view.
PDB entry 7nup coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mpakali A, Giastas P, Stratikos E

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180096 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Endoplasmic reticulum aminopeptidase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 966 amino acids
Theoretical weight: 111.43 KDa
Source organism: Homo sapiens
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: Q6P179 (Residues: 1-960; Coverage: 100%)
Gene names: ERAP2, LRAP
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
6 bound ligands:
Ligand ZN 4 x ZN
Ligand NAG 17 x NAG
Ligand USK 4 x USK
Ligand PGE 1 x PGE
Ligand EDO 3 x EDO
Ligand BR 13 x BR
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P1
Unit cell:
a: 74.273Å b: 127.186Å c: 133.412Å
α: 90.92° β: 90.08° γ: 90.87°
R-values:
R R work R free
0.186 0.182 0.267
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017

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