› 7nuw

X-ray diffraction
1.9Å resolution

Crystal structure of the TIR domain of human TLR1 (crystallised with Zn2+ ions)

Released:
DOI: 10.2210/pdb7nuw/pdb
PDB entry 7nuw coloured by chain, front view.
PDB entry 7nuw coloured by chain, side view.
PDB entry 7nuw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions.
Lushpa VA, Goncharuk MV, Lin C, Zalevsky AO, Talyzina IA, Luginina AP, Vakhrameev DD, Shevtsov MB, Goncharuk SA, Arseniev AS, Borshchevskiy VI, Wang X, Mineev KS
Commun Biol 4 1003 (2021)
PMID: 34429510

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172278 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 19.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15399 (Residues: 625-785; Coverage: 21%)
Gene names: KIAA0012, TLR1
Sequence domains: TIR domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P6222
Unit cell:
a: 101.516Å b: 101.516Å c: 68.86Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.215 0.245
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic Approach.
Manan et al. (2022)
2 more

1 mention without citation

Structural analysis of the Toll-like receptor 15 TIR domain.
Ko et al. (2023)