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› 7nz5

X-ray diffraction
1.9Å resolution

monomeric acetyl-CoA synthase with Zn at the proximal position of cluster A

Released:
DOI: 10.2210/pdb7nz5/pdb
Model geometry
Fit model/data
PDB entry 7nz5 coloured by chain, front view.
PDB entry 7nz5 coloured by chain, side view.
PDB entry 7nz5 coloured by chain, top view.
Source organism: Carboxydothermus hydrogenoformans Z-2901
Entry authors: Kreibich J, Jeoung JH, Dobbek H

Function and Biology Details

Reaction catalysed: 
Co(I)-[corrinoid Fe-S protein] + acetyl-CoA + H(+) = methyl-Co(III)-[corrinoid Fe-S protein] + CO + CoA.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174502 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CO-methylating acetyl-CoA synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 733 amino acids
Theoretical weight: 82.43 KDa
Source organism: Carboxydothermus hydrogenoformans Z-2901
Expression system: Escherichia coli M15
UniProt:
  • Canonical: Q3ACS4 (Residues: 1-732; Coverage: 100%)
Gene names: CHY_1222, acsB
Sequence domains:

Ligands and Environments

7 bound ligands:
Ligand SF4 2 x SF4
Ligand ZN 2 x ZN
Ligand NI 2 x NI
Ligand PEG 7 x PEG
Ligand CIT 3 x CIT
Ligand UW8 1 x UW8
Ligand BU3 2 x BU3
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 69.246Å b: 98.811Å c: 238.875Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.224
Expression system: Escherichia coli M15

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