› 7ocm

X-ray diffraction
1.7Å resolution

K1K1H6, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic

Released:
DOI: 10.2210/pdb7ocm/pdb
PDB entry 7ocm coloured by chain, front view.
PDB entry 7ocm coloured by chain, side view.
PDB entry 7ocm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
de Nola G, Leclercq B, Mougel A, Taront S, Simonneau C, Forneris F, Adriaenssens E, Drobecq H, Iamele L, Dubuquoy L, Melnyk O, Gherardi E, de Jonge H, Vicogne J
Life Sci Alliance 5 (2022)
PMID: 35905995

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146876 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor alpha chain Chain: A
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 20.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14210 (Residues: 125-268, 269-290; Coverage: 24%)
Gene names: HGF, HPTA
Sequence domains: Kringle domain

Ligands and Environments

1 bound ligand:
Ligand EPE 2 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 31.839Å b: 59.648Å c: 46.289Å
α: 90° β: 103.85° γ: 90°
R-values:
R R work R free
0.165 0.164 0.194
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Redox-Controlled Chemical Protein Synthesis: Sundry Shades of Latency.
Agouridas et al. (2022)

1 mention without citation

Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
de Nola et al. (2022)