Function and Biology Details
Reactions catalysed:
ATP + H(2)O = ADP + phosphate
S-adenosyl-L-methionine + cytosine(2870) in 25S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(2870) in 25S rRNA
S-adenosyl-L-methionine + guanosine(2922) in 27S pre-rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(2922) in 27S pre-rRNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- WD40 repeat
- Translation initiation factor IF6
- Large ribosomal subunit protein eL8, eukaryota
- P-loop containing nucleoside triphosphate hydrolase
- RNA (C5-cytosine) methyltransferase
- Large ribosomal subunit protein eL34
- Large ribosomal subunit protein uL30, ferredoxin-like fold domain superfamily
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
176 more domains
Structure analysis Details
Assembly composition:
hetero 51-mer (preferred)
PDBe Complex ID:
PDB-CPX-302053 (preferred)
Entry contents:
48 distinct polypeptide molecules
3 distinct RNA molecules
3 distinct RNA molecules
Macromolecules (51 distinct):
Ribosome biogenesis protein BRX1
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 33.59 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Sequence domains: Brix domain
Length: 291 amino acids
Theoretical weight: 33.59 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical:
Q08235 (Residues: 1-291; Coverage: 100%)
Sequence domains: Brix domain
Large ribosomal subunit protein uL3
Molecule details ›
Chain: B
Length: 387 amino acids
Theoretical weight: 43.85 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Sequence domains: Ribosomal protein L3
Length: 387 amino acids
Theoretical weight: 43.85 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical: P14126 (Residues: 1-387; Coverage: 100%)
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4A
ATP-dependent RNA helicase HAS1
Large ribosomal subunit protein eL6A
Large ribosomal subunit protein uL30A
Large ribosomal subunit protein eL8A
Large ribosomal subunit protein uL6A
Nucleolar complex-associated protein 3
rRNA-processing protein EBP2
Proteasome-interacting protein CIC1
Large ribosomal subunit protein eL13A
Large ribosomal subunit protein eL14A
Large ribosomal subunit protein eL15A
Large ribosomal subunit protein uL13A
Large ribosomal subunit protein uL22A
Large ribosomal subunit protein eL18A
Large ribosomal subunit protein eL19A
Large ribosomal subunit protein eL20A
Large ribosomal subunit protein eL22A
Large ribosomal subunit protein uL14A
Ribosome assembly factor MRT4
Large ribosomal subunit protein uL23
Large ribosomal subunit protein uL24A
Large ribosomal subunit protein eL27A
Nucleolar GTP-binding protein 1
Large ribosomal subunit protein eL30
Large ribosomal subunit protein eL31A
Large ribosomal subunit protein eL32
Large ribosomal subunit protein eL33A
Large ribosomal subunit protein eL34A
Large ribosomal subunit protein uL29A
Large ribosomal subunit protein eL36A
Large ribosomal subunit protein eL37A
Large ribosomal subunit protein eL38
60S ribosome subunit biogenesis protein NIP7
Ribosome biogenesis protein ERB1
Pescadillo homolog
Ribosome biogenesis protein 15
Ribosome biogenesis protein YTM1
25S rRNA (cytosine(2870)-C(5))-methyltransferase
Ribosome biogenesis protein NSA2
Nuclear GTP-binding protein NUG1
Ribosome biogenesis protein RLP7
Ribosome biogenesis protein RLP24
Nucleolar protein 16
27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase
Eukaryotic translation initiation factor 6
