7oix

Electron Microscopy
3.6Å resolution

Structure of thermostable human MFSD2A in complex with thermostable human Sync2

Released:
Source organism: Homo sapiens
Related structures: EMD-12935

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-158026 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Syncytin-2 Chain: A
Molecule details ›
Chain: A
Length: 538 amino acids
Theoretical weight: 59.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P60508 (Residues: 1-538; Coverage: 100%)
Gene names: ERVFRD-1, ERVFRDE1, UNQ6191/PRO20218
Sequence domains: ENV polyprotein (coat polyprotein)
Sodium-dependent lysophosphatidylcholine symporter 1 Chain: B
Molecule details ›
Chain: B
Length: 530 amino acids
Theoretical weight: 58.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NA29 (Residues: 1-543; Coverage: 98%)
Gene names: HMFN0656, MFSD2, MFSD2A, NLS1, PP9177, UNQ300/PRO341
Sequence domains: MFS/sugar transport protein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-12935
Expression system: Homo sapiens