› 7olv

X-ray diffraction
2.13Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171419 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Mer Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 34.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12866 (Residues: 571-864; Coverage: 30%)
Gene names: MER, MERTK
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

3 bound ligands:
Ligand VK2 1 x VK2
Ligand CL 4 x CL
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: C2221
Unit cell:
a: 91.379Å b: 92.541Å c: 71.387Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.247
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Small-molecule discovery through DNA-encoded libraries.
Peterson et al. (2023)
1 more