› 7otd

Solution NMR

Oxytocin NMR solution structure

Released:
DOI: 10.2210/pdb7otd/pdb
PDB entry 7otd coloured by chain, ensemble of 10 models, front view.
PDB entry 7otd coloured by chain, ensemble of 10 models, side view.
PDB entry 7otd coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Determining the structure and binding mechanism of oxytocin-Cu2+ complex using paramagnetic relaxation enhancement NMR analysis.
Alshanski I, Shalev DE, Yitzchaik S, Hurevich M
J Biol Inorg Chem 26 809-815 (2021)
PMID: 34459989

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134086 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxytocin Chain: A
Molecule details ›
Chain: A
Length: 9 amino acids
Theoretical weight: 1.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01178 (Residues: 20-28; Coverage: 9%)
Gene names: OT, OXT
Sequence domains: Neurohypophysial hormones, N-terminal Domain

Ligands and Environments

2 bound ligands:
Ligand CU 1 x CU
Ligand NH2 1 x NH2
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 47%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

3 review citations

Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists.
Cid-Jofré et al. (2021)
2 more

9 mentions without citation

Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects.
Sengupta et al. (2019)
8 more