› 7ots

X-ray diffraction
1.79Å resolution

Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside

Released:
DOI: 10.2210/pdb7ots/pdb
PDB entry 7ots coloured by chain, front view.
PDB entry 7ots coloured by chain, side view.
PDB entry 7ots coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Nawrotek A, Talagas A, Vuillard L, Miallau L

Function and Biology Details

Reaction catalysed: 
Hydrolyzes glycerol monoesters of long-chain fatty acids
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Monoacylglycerol lipase ABHD6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 297 amino acids
Theoretical weight: 33.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BV23 (Residues: 43-337; Coverage: 88%)
Gene name: ABHD6
Sequence domains: alpha/beta hydrolase fold

Ligands and Environments

4 bound ligands:
Ligand BOG 1 x BOG
Ligand OLA 2 x OLA
Ligand SO4 3 x SO4
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21
Unit cell:
a: 60.815Å b: 71.494Å c: 77.83Å
α: 90° β: 111.11° γ: 90°
R-values:
R R work R free
0.224 0.222 0.266
Expression system: Escherichia coli

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