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› 7ozy

X-ray diffraction
2.28Å resolution

FGFR2 kinase domain (residues 461-763) in complex with 38.

Released:
DOI: 10.2210/pdb7ozy/pdb
Model geometry
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PDB entry 7ozy coloured by chain, front view.
PDB entry 7ozy coloured by chain, side view.
PDB entry 7ozy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor.
Turner LD, Trinh CH, Hubball RA, Orritt KM, Lin CC, Burns JE, Knowles MA, Fishwick CWG
J Med Chem 65 1481-1504 (2022)
PMID: 34780700

Function and Biology Details

Reaction catalysed: 
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149426 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 2 Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 303 amino acids
Theoretical weight: 34.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21802 (Residues: 465-763; Coverage: 37%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

3 bound ligands:
Ligand 47I 2 x 47I
Ligand SO4 2 x SO4
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P43212
Unit cell:
a: 113.839Å b: 113.839Å c: 117.408Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.24 0.296
Expression system: Escherichia coli BL21(DE3)

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Citations

2 review citations

Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review.
Zheng et al. (2022)
1 more

3 mentions without citation

Anti-microbial, anti-oxidant, and anti-breast cancer properties unraveled in yeast carotenoids produced via cost-effective fermentation technique utilizing waste hydrolysate.
Sinha et al. (2022)
2 more

PDB-REDO

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