› 7p4b

X-ray diffraction
1.72Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-146751 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Soluble HLA class I histocompatibility antigen, alpha chain E Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 277 amino acids
Theoretical weight: 31.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia
UniProt:
  • Canonical: P13747 (Residues: 22-297; Coverage: 82%)
Gene names: HLA-6.2, HLA-E, HLAE
Sequence domains:
Beta-2-microglobulin Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
ESAT-6-like protein EsxH Chains: P, Q, R, Z
Molecule details ›
Chains: P, Q, R, Z
Length: 9 amino acids
Theoretical weight: 1.12 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia
UniProt:
  • Canonical: P9WNK3 (Residues: 4-12; Coverage: 9%)
Gene names: MTV035.16, Rv0288, cfp7, esxH

Ligands and Environments

4 bound ligands:
Ligand GOL 10 x GOL
Ligand SO4 16 x SO4
Ligand ZN 2 x ZN
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 244.562Å b: 48.529Å c: 153.161Å
α: 90° β: 116.948° γ: 90°
R-values:
R R work R free
0.203 0.201 0.237
Expression system: Escherichia

Quick links

Citations

1 review citation

Programming cytomegalovirus as an HIV vaccine.
Picker et al. (2023)
3 other articles