› 7pgt

Electron Microscopy
4.8Å resolution

The structure of human neurofibromin isoform 2 in opened conformation.

Released:
DOI: 10.2210/pdb7pgt/pdb
PDB entry 7pgt coloured by chain, front view.
PDB entry 7pgt coloured by chain, side view.
PDB entry 7pgt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of neurofibromin isoform 2 reveals different functional states.
Naschberger A, Baradaran R, Rupp B, Carroni M
Nature 599 315-319 (2021)
PMID: 34707296
Related structures: EMD-13395

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurofibromin Chains: F, N
Molecule details ›
Chains: F, N
Length: 2839 amino acids
Theoretical weight: 319.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21359 (Residues: 1-2839; Coverage: 100%)
Gene name: NF1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.8Å
Relevant EMDB volumes: EMD-13395
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

The Role of the Metabolism of Zinc and Manganese Ions in Human Cancerogenesis.
Rozenberg et al. (2022)
3 more

1 mention without citation

Current status and future perspectives of the evaluation of missense variants by using three-dimensional structures of proteins.
Shirota et al. (2022)