7phu

X-ray diffraction
2.53Å resolution

PfRH5 bound to monoclonal antibody R5.015 and R5.016 Fab fragments

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-226326 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Reticulocyte-binding protein homolog 5 Chain: A
Molecule details ›
Chain: A
Length: 501 amino acids
Theoretical weight: 60.05 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q8IFM5 (Residues: 26-526; Coverage: 100%)
Gene names: PF3D7_0424100, PFD1145c, RH5
Sequence domains: Rh5 coiled-coil domain
Monoclonal antibody R5.015 heavy chain Chain: B
Molecule details ›
Chain: B
Length: 236 amino acids
Theoretical weight: 25.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Monoclonal antibody R5.015 light chain Chain: C
Monoclonal antibody R5.016 heavy chain Chain: D
Monoclonal antibody R5.016 light chain Chain: E

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2221
Unit cell:
a: 97.74Å b: 163.3Å c: 176.82Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.276
Expression systems:
  • Drosophila melanogaster
  • Homo sapiens