› 7pk9

Electron Microscopy
2.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136119 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-reactive protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 206 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02741 (Residues: 19-224; Coverage: 100%)
Gene names: CRP, PTX1
Sequence domains: Pentaxin family

Ligands and Environments

1 bound ligand:
Ligand CA 20 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-13456
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation.
Noone et al. (2022)
2 more

1 mention without citation

Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein.
Noone et al. (2021)