› 7pvx

X-ray diffraction
1.43Å resolution

Crystal structure of the c-Src SH3 domain mutant E93V-S94A-R95S-T96G-N112G-N113Y-T114N-E115H in complex with the synthetic peptide VSL12

Released:
DOI: 10.2210/pdb7pvx/pdb
Model geometry
Fit model/data
PDB entry 7pvx coloured by chain, front view.
PDB entry 7pvx coloured by chain, side view.
PDB entry 7pvx coloured by chain, top view.
Source organisms:
Entry authors: Camara-Artigas A, Salinas Garcia MC

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132652 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proto-oncogene tyrosine-protein kinase Src Chains: A, C
Molecule details ›
Chains: A, C
Length: 60 amino acids
Theoretical weight: 6.6 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 82-141; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain
VSL12 peptide Chains: B, D
Molecule details ›
Chains: B, D
Length: 12 amino acids
Theoretical weight: 1.32 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: P21
Unit cell:
a: 28.991Å b: 59.658Å c: 37.349Å
α: 90° β: 98.62° γ: 90°
R-values:
R R work R free
0.176 0.174 0.21
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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