› 7px8

Electron Microscopy
3.27Å resolution

CryoEM structure of mammalian acylaminoacyl-peptidase

Released:
DOI: 10.2210/pdb7px8/pdb
PDB entry 7px8 coloured by chain, front view.
PDB entry 7px8 coloured by chain, side view.
PDB entry 7px8 coloured by chain, top view.
Source organism: Sus scrofa domesticus
Primary publication:
Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad.
Kiss-Szemán AJ, Stráner P, Jákli I, Hosogi N, Harmat V, Menyhárd DK, Perczel A
Chem Sci 13 7132-7142 (2022)
PMID: 35799812
Related structures: EMD-13691

Function and Biology Details

Reaction catalysed: 
Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acylamino-acid-releasing enzyme Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 732 amino acids
Theoretical weight: 81.32 KDa
Source organism: Sus scrofa domesticus
UniProt:
  • Canonical: P19205 (Residues: 1-732; Coverage: 100%)
Gene name: APEH
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.27Å
Relevant EMDB volumes: EMD-13691

Quick links

Citations

2 citation in other articles

Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and x-ray crystallography.
Chmelova et al. (2023)
1 more

2 mentions without citation

Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad.
Kiss-Szemán et al. (2022)
1 more