› 7pxh

Electron Microscopy
2.59Å resolution

Emodepside-bound Drosophila Slo channel

Released:
DOI: 10.2210/pdb7pxh/pdb
PDB entry 7pxh coloured by chain, front view.
PDB entry 7pxh coloured by chain, side view.
PDB entry 7pxh coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM.
Raisch T, Brockmann A, Ebbinghaus-Kintscher U, Freigang J, Gutbrod O, Kubicek J, Maertens B, Hofnagel O, Raunser S
Nat Commun 12 7164 (2021)
PMID: 34887422
Related structures: EMD-13703

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169939 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-activated potassium channel slowpoke Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1180 amino acids
Theoretical weight: 130.92 KDa
Source organism: Drosophila melanogaster
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q03720 (Residues: 1-1200; Coverage: 98%)
  • Best match: Q03720-14 (Residues: 1-1180)
Gene names: CG10693, slo
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand CA 8 x CA
Ligand MG 4 x MG
Ligand 6PL 16 x 6PL
Ligand CLR 4 x CLR
Ligand K 6 x K
Ligand 8I2 1 x 8I2
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.59Å
Relevant EMDB volumes: EMD-13703
Expression system: Trichoplusia ni

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Citations

1 citations in other articles

The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins.
Xu et al. (2023)