› 7pzf

X-ray diffraction
1.5Å resolution

Crystal structure of the OmpK36 TD insertion chimera from Klebsiella pneumonia

Released:
DOI: 10.2210/pdb7pzf/pdb
PDB entry 7pzf coloured by chain, front view.
PDB entry 7pzf coloured by chain, side view.
PDB entry 7pzf coloured by chain, top view.
Source organism: Klebsiella pneumoniae
Primary publication:
Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae.
David S, Wong JLC, Sanchez-Garrido J, Kwong HS, Low WW, Morecchiato F, Giani T, Rossolini GM, Brett SJ, Clements A, Beis K, Aanensen DM, Frankel G
PLoS Pathog 18 e1010334 (2022)
PMID: 35816554

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112799 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
OmpK36 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 347 amino acids
Theoretical weight: 38.28 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli
UniProt:
  • Canonical: D6QLY2 (Residues: 22-135, 138-367; Coverage: 99%)
Gene name: ompK36
Sequence domains: Gram-negative porin

Ligands and Environments

2 bound ligands:
Ligand LI 9 x LI
Ligand C14 21 x C14
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 55.106Å b: 73.428Å c: 158.837Å
α: 91.12° β: 97.17° γ: 103.09°
R-values:
R R work R free
0.191 0.19 0.205
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Evaluation of Antibiotic Resistance Mechanisms in Gram-Negative Bacteria.
Gauba et al. (2023)
2 more

1 mention without citation

Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae.
David et al. (2022)