Function and Biology Details
Reaction catalysed:
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase, pyridoxal phosphate binding site
- Pyridoxal phosphate-dependent transferase, major domain
- Pyridoxal phosphate-dependent transferase, small domain
- Serine hydroxymethyltransferase-like domain
- Pyridoxal phosphate-dependent transferase
- Pleckstrin homology domain
Structure analysis Details
Assembly composition:
homo tetramer (preferred)
Assembly name:
Serine hydroxymethyltransferase 2, mitochondrial (preferred)
PDBe Complex ID:
PDB-CPX-188223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine hydroxymethyltransferase 2, mitochondrial
Molecule details ›
Chains: A, B, C, D
Length: 480 amino acids
Theoretical weight: 53.77 KDa
Source organism: Arabidopsis thaliana
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
Sequence domains: Serine hydroxymethyltransferase
Length: 480 amino acids
Theoretical weight: 53.77 KDa
Source organism: Arabidopsis thaliana
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
- Canonical:
Q94C74 (Residues: 41-517; Coverage: 92%)
Sequence domains: Serine hydroxymethyltransferase
Ligands and Environments
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
APS BEAMLINE 22-BM
Spacegroup:
P212121
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
