› 7q4q

X-ray diffraction
1.65Å resolution

Magacizumab Fab fragment in complex with human LRG1 epitope

Released:
DOI: 10.2210/pdb7q4q/pdb
Model geometry
Fit model/data
PDB entry 7q4q coloured by chain, front view.
PDB entry 7q4q coloured by chain, side view.
PDB entry 7q4q coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of human LRG1 recognition by Magacizumab, a humanized monoclonal antibody with therapeutic potential.
Gutiérrez-Fernández J, Javaid F, De Rossi G, Chudasama V, Greenwood J, Moss SE, Luecke H
OpenAccess logo Acta Crystallogr D Struct Biol 78 725-734 (2022)
PMID: 35647920

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208782 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Magacizumab light chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 218 amino acids
Theoretical weight: 23.91 KDa
Source organism: Mus musculus
Magacizumab heavy chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 220 amino acids
Theoretical weight: 23.56 KDa
Source organism: Mus musculus
Leucine-rich alpha-2-glycoprotein Chains: E, F

Ligands and Environments

1 bound ligand:
Ligand TRS 2 x TRS
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P212121
Unit cell:
a: 64.549Å b: 76.978Å c: 217.731Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.207
Expression system: Not provided

Quick links

Citations

2 citation in other articles

DIA-based technology explores hub pathways and biomarkers of neurological recovery in ischemic stroke after rehabilitation.
Hu et al. (2023)
1 more

2 mentions without citation

Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity.
Davies et al. (2023)
1 more