› 7q9b

X-ray diffraction
3.24Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-242995 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Ig-like domain-containing protein Chains: AAA, FFF
Molecule details ›
Chains: AAA, FFF
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A140T913 (Residues: 25-299; Coverage: 79%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chains: BBB, GGG
Molecule details ›
Chains: BBB, GGG
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Melanoma antigen recognized by T-cells 1 Chains: CCC, HHH
Human T Cell Receptor Mel8, Alpha Chain Chains: DDD, III
Ig-like domain-containing protein Chains: EEE, JJJ

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 99.972Å b: 53.645Å c: 203.507Å
α: 90° β: 94.333° γ: 90°
R-values:
R R work R free
0.229 0.226 0.276
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

10 review citations

CD8<sup>+</sup> T cells in the cancer-immunity cycle.
Giles et al. (2023)
9 more