› 7qac

X-ray powder diffraction
2.29Å resolution

The T2 structure of polycrystalline cubic human insulin

Released:
DOI: 10.2210/pdb7qac/pdb
PDB entry 7qac coloured by chain, front view.
PDB entry 7qac coloured by chain, side view.
PDB entry 7qac coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The T2 structure of polycrystalline cubic human insulin.
Triandafillidis DP, Karavassili F, Spiliopoulou M, Valmas A, Athanasiadou M, Nikolaras G, Fili S, Kontou P, Bowler MW, Chasapis CT, Von Dreele RB, Fitch AN, Margiolaki I
Acta Crystallogr D Struct Biol 79 374-386 (2023)
PMID: 37039669

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134182 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chain: B
Molecule details ›
Chain: B
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID22, MALVERN PANALYTICAL EMPYREAN TUBE
Spacegroup: I213
Unit cell:
a: 78.86Å b: 78.86Å c: 78.86Å
α: 90° β: 90° γ: 90°
Expression system: Saccharomyces cerevisiae

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Citations

1 mention without citation

The T2 structure of polycrystalline cubic human insulin.
Triandafillidis et al. (2023)