› 7qcy

Solution NMR

Two-state liquid NMR Structure of a PDZ2 Domain from hPTP1E, complexed with RA-GEF2 peptide

Released:
DOI: 10.2210/pdb7qcy/pdb
PDB entry 7qcy coloured by chain, ensemble of 40 models, front view.
PDB entry 7qcy coloured by chain, ensemble of 40 models, side view.
PDB entry 7qcy coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Primary publication:
Atomic resolution protein allostery from the multi-state structure of a PDZ domain.
Ashkinadze D, Kadavath H, Pokharna A, Chi CN, Friedmann M, Strotz D, Kumari P, Minges M, Cadalbert R, Königl S, Güntert P, Vögeli B, Riek R
OpenAccess logo Nat Commun 13 6232 (2022)
PMID: 36266302

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171438 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 13 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q12923 (Residues: 1361-1456; Coverage: 4%)
Gene names: PNP1, PTP1E, PTPL1, PTPN13
Sequence domains: PDZ domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 73%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

6 citation in other articles

MDiGest: A Python package for describing allostery from molecular dynamics simulations.
Maschietto et al. (2023)
5 more