› 7qdi

X-ray diffraction
2.34Å resolution

Structure of octameric left-handed 310-helix bundle: D-310HD

Released:
DOI: 10.2210/pdb7qdi/pdb
PDB entry 7qdi coloured by chain, front view.
PDB entry 7qdi coloured by chain, side view.
PDB entry 7qdi coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
De novo design of discrete, stable 310-helix peptide assemblies.
Kumar P, Paterson NG, Clayden J, Woolfson DN
Nature (2022)
PMID: 35732733

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D-310HD Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 33 amino acids
Theoretical weight: 3.38 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

8 bound ligands:
Ligand PGE 2 x PGE
Ligand EDO 14 x EDO
Ligand SO4 3 x SO4
Ligand PEG 8 x PEG
Ligand PG0 1 x PG0
Ligand PG6 1 x PG6
Ligand BO3 2 x BO3
Ligand PG4 1 x PG4
4 modified residues:
Ligand DGL 32 x DGL
Ligand DLE 64 x DLE
Ligand AIB 88 x AIB
Ligand DLY 40 x DLY

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Unit cell:
a: 33.238Å b: 44.976Å c: 194.192Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.188 0.239
Expression system: Not provided

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Citations

2 review citations

Screw sense and screw sensibility: communicating information by conformational switching in helical oligomers.
Morris et al. (2023)
1 more