› 7qfc

X-ray diffraction
2.6Å resolution

Crystal structure of cytotoxin 13 from Naja naja, orthorhombic form

Released:
DOI: 10.2210/pdb7qfc/pdb
PDB entry 7qfc coloured by chain, front view.
PDB entry 7qfc coloured by chain, side view.
PDB entry 7qfc coloured by chain, top view.
Source organism: Naja naja
Primary publication:
Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling.
Dubovskii PV, Dubova KM, Bourenkov G, Starkov VG, Konshina AG, Efremov RG, Utkin YN, Samygina VR
Toxins (Basel) 14 (2022)
PMID: 35202176

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UPAR/Ly6 domain-containing protein Chains: AAA, BBB, CCC, DDD, EEE, FFF
Molecule details ›
Chains: AAA, BBB, CCC, DDD, EEE, FFF
Length: 60 amino acids
Theoretical weight: 6.76 KDa
Source organism: Naja naja
UniProt:
  • Canonical: A0A0U4N5W4 (Residues: 13-72; Coverage: 83%)
Gene name: CTX13
Sequence domains: u-PAR/Ly-6 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: C2221
Unit cell:
a: 88.759Å b: 97.175Å c: 131.917Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.255

Quick links

Citations

2 review citations

Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy.
Kalita et al. (2022)
1 more

1 mention without citation

Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling.
Dubovskii et al. (2022)