› 7qk5

Electron Microscopy
1.92Å resolution

In vitro assembled 266/297 - 391 tau filaments with KCl (10a)

Released:
DOI: 10.2210/pdb7qk5/pdb
PDB entry 7qk5 coloured by chain, front view.
PDB entry 7qk5 coloured by chain, side view.
PDB entry 7qk5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy.
Lövestam S, Koh FA, van Knippenberg B, Kotecha A, Murzin AG, Goedert M, Scheres SHW
Elife 11 (2022)
PMID: 35244536
Related structures: EMD-14038

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F, G, H, K
Molecule details ›
Chains: A, B, C, D, E, F, G, H, K
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

2 bound ligands:
Ligand CL 18 x CL
Ligand K 18 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 1.92Å
Relevant EMDB volumes: EMD-14038

Quick links

Citations

13 review citations

NLRP3 inflammasome in neurodegenerative disease.
Anderson et al. (2023)
12 more

1 mention without citation

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.
Pinzi et al. (2023)