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› 7qq0

X-ray diffraction
1.32Å resolution

X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (2)

Released:
DOI: 10.2210/pdb7qq0/pdb
Model geometry
Fit model/data
Data not analysed
PDB entry 7qq0 coloured by chain, front view.
PDB entry 7qq0 coloured by chain, side view.
PDB entry 7qq0 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Reactivity of a fluorine-containing dirhodium tetracarboxylate compound with proteins.
Loreto D, Esposito A, Demitri N, Guaragna A, Merlino A
Dalton Trans 51 3695-3705 (2022)
PMID: 35166290

Function and Biology Details

Reaction catalysed: 
(1) an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158390 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease pancreatic Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 124 amino acids
Theoretical weight: 13.71 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P61823 (Residues: 27-150; Coverage: 100%)
Gene names: RNASE1, RNS1
Sequence domains: Pancreatic ribonuclease

Ligands and Environments

2 bound ligands:
Ligand F3I 2 x F3I
Ligand RHF 2 x RHF
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ELETTRA BEAMLINE 11.2C
Spacegroup: C2
Unit cell:
a: 100.21Å b: 32.56Å c: 72.61Å
α: 90° β: 90.309° γ: 90°
R-values:
R R work R free
0.21 0.209 0.243

Quick links

Citations

4 citation in other articles

A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action.
La Manna et al. (2024)
3 more