› 7qtq

Electron Microscopy
3.3Å resolution

Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids.

Released:
DOI: 10.2210/pdb7qtq/pdb
PDB entry 7qtq coloured by chain, front view.
PDB entry 7qtq coloured by chain, side view.
PDB entry 7qtq coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
Marechal N, Serrano BP, Zhang X, Weitz CJ
Nat Commun 13 2380 (2022)
PMID: 35501346
Related structures: EMD-14145

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134139 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Thyroglobulin Chains: A, B
Molecule details ›
Chains: A, B
Length: 2769 amino acids
Theoretical weight: 304.04 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P01267 (Residues: 1-2769; Coverage: 100%)
Gene name: TG
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 12 x NAG
1 modified residue:
Ligand DHA 2 x DHA

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-14145

Quick links

Citations

1 review citation

Defective Thyroglobulin: Cell Biology of Disease.
Zhang et al. (2022)
3 other articles

1 mention without citation

Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
Marechal et al. (2022)