› 7r1o

X-ray diffraction
2.2Å resolution

p62-ZZ domain of the human sequestosome in complex with dusquetide

Released:
DOI: 10.2210/pdb7r1o/pdb
PDB entry 7r1o coloured by chain, front view.
PDB entry 7r1o coloured by chain, side view.
PDB entry 7r1o coloured by chain, top view.
Source organisms:
Primary publication:
Dusquetide modulates innate immune response through binding to p62.
Zhang Y, Towers CG, Singh UK, Liu J, Håkansson M, Logan DT, Donini O, Kutateladze TG
Structure (2022)
PMID: 35640615

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168717 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sequestosome-1 Chains: AAA, BBB, CCC, DDD
Molecule details ›
Chains: AAA, BBB, CCC, DDD
Length: 53 amino acids
Theoretical weight: 5.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13501 (Residues: 120-172; Coverage: 12%)
Gene names: ORCA, OSIL, SQSTM1
Sequence domains: Zinc finger, ZZ type
Dusquetide Chains: EEE, FFF
Molecule details ›
Chains: EEE, FFF
Length: 5 amino acids
Theoretical weight: 556 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 8 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: C2
Unit cell:
a: 124.07Å b: 25.15Å c: 77.53Å
α: 90° β: 124.915° γ: 90°
R-values:
R R work R free
0.181 0.178 0.243
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

2 mentions without citation

Dusquetide modulates innate immune response through binding to p62.
Zhang et al. (2022)
1 more