› 7rdb

X-ray diffraction
2.52Å resolution

Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL)

Released:
DOI: 10.2210/pdb7rdb/pdb
PDB entry 7rdb coloured by chain, front view.
PDB entry 7rdb coloured by chain, side view.
PDB entry 7rdb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
Lipper CH, Gabriel KH, Seegar TCM, Dürr KL, Tomlinson MG, Blacklow SC
Structure 30 206-214.e4 (2022)
PMID: 34739841

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132071 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tetraspanin-15 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Length: 122 amino acids
Theoretical weight: 14.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95858 (Residues: 115-230; Coverage: 40%)
Gene names: NET7, TM4SF15, TSPAN15, UNQ677/PRO1311
Sequence domains: Tetraspanin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 83.57Å b: 91.95Å c: 112.38Å
α: 87.552° β: 86.519° γ: 86.241°
R-values:
R R work R free
0.236 0.235 0.273
Expression system: Homo sapiens

Quick links

Citations

2 review citations

ADAM10-a "multitasker" in sepsis: focus on its posttranslational target.
Liao et al. (2023)
1 more

2 mentions without citation

Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
Lipper et al. (2022)
1 more