› 7rdl

X-ray diffraction
2.71Å resolution

Crystal structure of PCDN-22A, an anti-HIV antibody from the PCDN bnAb lineage

Released:
DOI: 10.2210/pdb7rdl/pdb
PDB entry 7rdl coloured by chain, front view.
PDB entry 7rdl coloured by chain, side view.
PDB entry 7rdl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and Biochemical Characterization of Cysteinylation in Broadly Neutralizing Antibodies to HIV-1.
Omorodion O, Wilson IA
J Mol Biol 433 167303 (2021)
PMID: 34666044

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214435 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PCDN-22A Fab light chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 216 amino acids
Theoretical weight: 23.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
PCDN-22A Fab heavy chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 232 amino acids
Theoretical weight: 24.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand TRS 2 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 70.079Å b: 105.471Å c: 145.926Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.23 0.258
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Editorial: Mechanisms and strategies of unconventional antibody diversification for greater immune adaptability.
Dimitrov et al. (2023)

1 mention without citation

Structural and Biochemical Characterization of Cysteinylation in Broadly Neutralizing Antibodies to HIV-1.
Omorodion et al. (2021)