7rh7

Electron Microscopy
3Å resolution

Mycobacterial CIII2CIV2 supercomplex, Telacebec (Q203) bound

Released:

Function and Biology Details

Reactions catalysed:
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 24-mer (preferred)
PDBe Complex ID:
PDB-CPX-106256 (preferred)
Entry contents:
12 distinct polypeptide molecules
Macromolecules (12 distinct):
LpqE protein Chains: W, c
Molecule details ›
Chains: W, c
Length: 159 amino acids
Theoretical weight: 16.41 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R562 (Residues: 24-182; Coverage: 98%)
Gene name: MSMEG_6078
cytochrome-c oxidase Chains: K, Q
Molecule details ›
Chains: K, Q
Length: 312 amino acids
Theoretical weight: 35.2 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R057 (Residues: 27-338; Coverage: 92%)
Gene name: MSMEG_4268
Sequence domains: Cytochrome C oxidase subunit II, periplasmic domain
Cytochrome c oxidase subunit 1 Chains: L, R
Molecule details ›
Chains: L, R
Length: 552 amino acids
Theoretical weight: 61.73 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Probable cytochrome c oxidase subunit 3 Chains: S, X
Molecule details ›
Chains: S, X
Length: 203 amino acids
Theoretical weight: 22.2 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R049 (Residues: 1-203; Coverage: 100%)
Gene name: MSMEG_4260
Sequence domains: Cytochrome c oxidase subunit III
Cytochrome c oxidase polypeptide 4 Chains: T, Z
Molecule details ›
Chains: T, Z
Length: 139 amino acids
Theoretical weight: 15.18 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R056 (Residues: 1-139; Coverage: 100%)
Gene name: MSMEG_4267
Sequence domains: Cytochrome c oxidase subunit IV
Cytochrome c oxidase subunit CtaJ Chains: U, a
Molecule details ›
Chains: U, a
Length: 79 amino acids
Theoretical weight: 8.37 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R1B6 (Residues: 1-79; Coverage: 100%)
Gene name: MSMEG_4693
Uncharacterized protein MSMEG_4692/MSMEI_4575 Chains: V, b
Molecule details ›
Chains: V, b
Length: 145 amino acids
Theoretical weight: 14.81 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R1B5 (Residues: 13-157; Coverage: 92%)
Gene names: MSMEG_4692, MSMEI_4575
Sequence domains: Domain of unknown function (DUF5130)
Transmembrane protein Chains: J, P
Molecule details ›
Chains: J, P
Length: 100 amino acids
Theoretical weight: 11.33 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0QVH4 (Residues: 2-84; Coverage: 99%)
Gene name: MSMEG_2575
Sequence domains: Protein of unknown function (DUF2631)
Superoxide dismutase [Cu-Zn] Chains: D, G
Molecule details ›
Chains: D, G
Length: 216 amino acids
Theoretical weight: 21.22 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0QQQ1 (Residues: 21-236; Coverage: 100%)
Gene names: MSMEG_0835, sodC
Sequence domains: Copper/zinc superoxide dismutase (SODC)
Cytochrome bc1 complex cytochrome c subunit Chains: I, O
Molecule details ›
Chains: I, O
Length: 223 amino acids
Theoretical weight: 23.18 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: I7FPH1 (Residues: 72-294; Coverage: 76%)
Gene names: MSMEI_4161, qcrC
Sequence domains:
Cytochrome bc1 complex cytochrome b subunit Chains: E, F
Molecule details ›
Chains: E, F
Length: 535 amino acids
Theoretical weight: 59.11 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R052 (Residues: 4-538; Coverage: 98%)
Gene name: MSMEG_4263
Sequence domains: Cytochrome b(N-terminal)/b6/petB
Cytochrome bc1 complex Rieske iron-sulfur subunit Chains: M, Y
Molecule details ›
Chains: M, Y
Length: 382 amino acids
Theoretical weight: 42.21 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: I7GD61 (Residues: 40-421; Coverage: 91%)
Gene names: MSMEI_4162, qcrA
Sequence domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-24457