› 7rhs

Electron Microscopy
2.93Å resolution

Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel

Released:
DOI: 10.2210/pdb7rhs/pdb
PDB entry 7rhs coloured by chain, front view.
PDB entry 7rhs coloured by chain, side view.
PDB entry 7rhs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human cone photoreceptor cyclic nucleotide-gated channel.
Zheng X, Hu Z, Li H, Yang J
Nat Struct Mol Biol 29 40-46 (2022)
PMID: 34969976
Related structures: EMD-24468

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172459 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclic nucleotide-gated channel alpha-3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 706 amino acids
Theoretical weight: 80.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16281 (Residues: 1-694; Coverage: 100%)
Gene names: CNCG3, CNGA3
Sequence domains:
Cyclic nucleotide-gated channel beta-3 Chain: D
Molecule details ›
Chain: D
Length: 841 amino acids
Theoretical weight: 95.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NQW8 (Residues: 2-809; Coverage: 100%)
Gene name: CNGB3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.93Å
Relevant EMDB volumes: EMD-24468
Expression system: Homo sapiens

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Citations

6 review citations

Biology, Pathobiology and Gene Therapy of CNG Channel-Related Retinopathies.
Gerhardt et al. (2023)
5 more

4 mentions without citation

Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels.
Hu et al. (2023)
3 more