› 7rjn

X-ray diffraction
1.95Å resolution

Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with BCLTF1

Released:
DOI: 10.2210/pdb7rjn/pdb
Model geometry
Fit model/data
PDB entry 7rjn coloured by chain, front view.
PDB entry 7rjn coloured by chain, side view.
PDB entry 7rjn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Uncovering the Bromodomain Interactome using Site-Specific Azide-Acetyllysine Photochemistry, Proteomic Profiling and Structural Characterization
Wagner S, Fedorov E, Sudhamalla B, Jnawali HN, Debiec R, Ghosh A, Islam K
Biorxiv (2021)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172181 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15059 (Residues: 24-144; Coverage: 17%)
Gene names: BRD3, KIAA0043, RING3L
Sequence domains: Bromodomain
Bcl-2-associated transcription factor 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.24 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NYF8 (Residues: 330-339; Coverage: 1%)
Gene names: BCLAF1, BTF, KIAA0164

Ligands and Environments

1 bound ligand:
Ligand EDO 3 x EDO
1 modified residue:
Ligand ALY 4 x ALY

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS-II BEAMLINE 17-ID-1
Spacegroup: P212121
Unit cell:
a: 42.729Å b: 54.793Å c: 122.242Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.234
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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