› 7rjz

X-ray diffraction
1.7Å resolution

BthTX-II variant a, from Bothrops jararacussu venom, complexed with benzoic acid

Released:
DOI: 10.2210/pdb7rjz/pdb
PDB entry 7rjz coloured by chain, front view.
PDB entry 7rjz coloured by chain, side view.
PDB entry 7rjz coloured by chain, top view.
Source organism: Bothrops jararacussu
Primary publication:
BthTX-II from Bothrops jararacussu venom has variants with different oligomeric assemblies: An example of snake venom phospholipases A2 versatility.
Borges RJ, Salvador GHM, Campanelli HB, Pimenta DC, de Oliveira Neto M, Usón I, Fontes MRM
Int J Biol Macromol 191 255-266 (2021)
PMID: 34547312

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog bothropstoxin-II Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 13.74 KDa
Source organism: Bothrops jararacussu
UniProt:
  • Canonical: P45881 (Residues: 17-138; Coverage: 99%)
Sequence domains: Phospholipase A2

Ligands and Environments

1 bound ligand:
Ligand BEZ 2 x BEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P21212
Unit cell:
a: 60.4Å b: 107.37Å c: 44.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.222

Quick links

Citations

1 review citation

Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its Elusive Mechanisms of Reaction.
Castro-Amorim et al. (2023)
2 other articles