› 7rm5

Electron crystallography
2.79Å resolution

MicroED structure of the human adenosine receptor at 2.8A

Released:
DOI: 10.2210/pdb7rm5/pdb
PDB entry 7rm5 coloured by chain, front view.
PDB entry 7rm5 coloured by chain, side view.
PDB entry 7rm5 coloured by chain, top view.
Source organisms:
Primary publication:
MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP.
Martynowycz MW, Shiriaeva A, Ge X, Hattne J, Nannenga BL, Cherezov V, Gonen T
Proc Natl Acad Sci U S A 118 (2021)
PMID: 34462357
Related structures: EMD-24551

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine receptor A2a; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 447 amino acids
Theoretical weight: 49.97 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29274 (Residues: 2-208, 219-316; Coverage: 74%)
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
Gene names: ADORA2, ADORA2A, cybC
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ZMA 1 x ZMA
Ligand CLR 4 x CLR
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.79Å
Relevant EMDB volumes: EMD-24551
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

Better, Faster, Cheaper: Recent Advances in Cryo-Electron Microscopy.
Chua et al. (2022)
5 more

4 mentions without citation

International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update.
IJzerman et al. (2022)
3 more