› 7rpm

Solution NMR

Structures of the Intracellular Domain and Transmembrane Domain of the Human alpha7 Nicotinic Acetylcholine Receptors

Released:
DOI: 10.2210/pdb7rpm/pdb
PDB entry 7rpm coloured by chain, ensemble of 15 models, front view.
PDB entry 7rpm coloured by chain, ensemble of 15 models, side view.
PDB entry 7rpm coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor.
Bondarenko V, Wells MM, Chen Q, Tillman TS, Singewald K, Lawless MJ, Caporoso J, Brandon N, Coleman JA, Saxena S, Lindahl E, Xu Y, Tang P
Nat Commun 13 793 (2022)
PMID: 35145092

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153193 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuronal acetylcholine receptor subunit alpha-7 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 272 amino acids
Theoretical weight: 29.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P36544 (Residues: 231-496; Coverage: 55%)
Gene names: CHRNA7, NACHRA7
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 12%
Refinement method: na
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Novel machine learning approaches revolutionize protein knowledge.
Bordin et al. (2023)
2 more

5 mentions without citation

Protein Data Bank: A Comprehensive Review of 3D Structure Holdings and Worldwide Utilization by Researchers, Educators, and Students.
Burley et al. (2022)
4 more