› 7s5h

X-ray diffraction
1.27Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168765 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NBP7 (Residues: 31-152; Coverage: 18%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Proprotein convertase subtilisin/kexin type 9 Chain: B
Molecule details ›
Chain: B
Length: 308 amino acids
Theoretical weight: 32.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-452; Coverage: 45%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Subtilase family
Z50-DNP-DAL-PHE-FTR-PRO-THR-0A1-3WX Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.36 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand 89N 1 x 89N
5 modified residues:
Ligand DNP 1 x DNP
Ligand DAL 1 x DAL
Ligand FTR 1 x FTR
Ligand 0A1 1 x 0A1
Ligand 3WX 1 x 3WX

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 44.25Å b: 72.487Å c: 105.112Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.206 0.209
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

10 review citations

Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond.
Seidah et al. (2022)
9 more

4 mentions without citation

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Johns et al. (2023)
3 more